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The significance of anti-idiotypic antibody in pregnancy

✍ Scribed by Toshihiko Mizuno; Koji Aoki; Toshihiro Kimbara; Ronit Wolf-Levin; Yoshiaki Yagami


Book ID
119090950
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
67 KB
Volume
15
Category
Article
ISSN
0165-0378

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## Abstract We raised an antihuman thyrotropin anti‐idiotypic antibody and showed that it was active at the thyrotropin receptor. Thus this antibody inhibited ^125^I b‐TSH binding to thyroid plasma membranes, stimulated adenylate cyclase activity through a guanyl nucleotide‐dependent mechanism, inc