✦ LIBER ✦

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery

✍ Scribed by Jasna Fejzo; Christopher A Lepre; Jeffrey W Peng; Guy W Bemis; Ajay; Mark A Murcko; Jonathan M Moore

Book ID: 108485932
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 197 KB
Volume: 6
Category: Article
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(00)80022-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

NMR experiments for lead generation in d

NMR experiments for lead generation in drug discovery

✍ Jeffrey W. Peng; Jonathan Moore; Norzehan Abdul-Manan 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 734 KB

Lead Generation Approaches in Drug Disco

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Lead Discovery: The Process

✍ Rankovic, Zoran; Morphy, Richard 📂 Article 📅 2010 🏛 John Wiley & Sons, Inc. ⚖ 288 KB 👁 1 views

Lead Generation Approaches in Drug Disco

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Early Screening for ADMET Properties

✍ Rankovic, Zoran; Morphy, Richard 📂 Article 📅 2010 🏛 John Wiley & Sons, Inc. ⚖ 372 KB 👁 1 views

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Fragmentâbased Approaches in Drug Discovery || SAR by NMR: An Analysis of Potency Gains Realized Through Fragmentâlinking and Fragmentâelaboration Strategies for Lead Generation

✍ Jahnke, Wolfgang; Erlanson, Daniel A. 📂 Article 📅 2006 🏛 Wiley ⚖ 344 KB 👁 1 views

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Fragmentâbased Approaches in Drug Discovery || Pyramid: An Integrated Platform for Fragmentâbased Drug Discovery

✍ Jahnke, Wolfgang; Erlanson, Daniel A. 📂 Article 📅 2006 🏛 Wiley ⚖ 327 KB 👁 1 views

drug discovery" [6-8, 11, 12] has a number of other advantages over conventional screening, including a more efficient sampling of chemical space and a higher hitrate due to lower molecular complexity [13]. Both of these factors mean that the number of compounds screened can be considerably reduced.

[Methods and Principles in Medicinal Che

[Methods and Principles in Medicinal Chemistry] Fragmentâbased Approaches in Drug Discovery || Synergistic Use of Protein Crystallography and Solutionâphase NMR Spectroscopy in Structureâbased Drug Design: Strategies and Tactics

✍ Jahnke, Wolfgang; Erlanson, Daniel A. 📂 Article 📅 2006 🏛 Wiley ⚖ 303 KB 👁 1 views