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[Methods and Principles in Medicinal Chemistry] Fragment‐based Approaches in Drug Discovery || SAR by NMR: An Analysis of Potency Gains Realized Through Fragment‐linking and Fragment‐elaboration Strategies for Lead Generation

✍ Scribed by Jahnke, Wolfgang; Erlanson, Daniel A.

Publisher
Wiley
Year
2006
Weight
344 KB
Category
Article
ISBN
3527608761

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[Methods and Principles in Medicinal Chemistry] Fragment‐based Approaches in Drug Discovery || Pyramid: An Integrated Platform for Fragment‐based Drug Discovery
✍ Jahnke, Wolfgang; Erlanson, Daniel A. 📂 Article 📅 2006 🏛 Wiley ⚖ 327 KB 👁 1 views

drug discovery" [6-8, 11, 12] has a number of other advantages over conventional screening, including a more efficient sampling of chemical space and a higher hitrate due to lower molecular complexity [13]. Both of these factors mean that the number of compounds screened can be considerably reduced.