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The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

✍ Scribed by Stefansson, Steingrimur; Lawrence, Daniel A.


Book ID
109798032
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
662 KB
Volume
383
Category
Article
ISSN
0028-0836

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## Abstract The interaction between the arginine glycine and aspartic acid motif (RGD) of integrin ligands such as vitronectin and the integrin receptor αVβ3 in mediating cell attachment has been well described. Similarly, the ability of disintegrins, small RGD containing peptides, to inhibit cell