Cell-matrix interactions are thought to be of critical importance in the regulation of various cell functions, including proliferation, migration and control of gene expression. The integrins, a large family of specific receptors for the macromolecules of the extracellular matrix, are important medi
✦ LIBER ✦
Migration properties of the human ovarian adenocarcinoma cell line IGROV1: Importance of αvβ3 integrins and vitronectin
✍ Scribed by Franck Carreiras; Véronique Rigot; Séverine Cruet; Frédéric André; Pascal Gauduchon; Jacques Marvaldi
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 453 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0020-7136
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Bone sialoprotein (BSP), a secreted glycoprotein found in bone matrix, has been implicated in the formation of mammary microcalcifications and osteotropic metastasis of human breast cancer (HBC). BSP possesses an integrin-binding RGD (Arg-Gly-Asp) domain, which may promote interactions between HBC c