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The Sensitivity of Cells in Exponential and Stationary Phases of Growth to Bleomycin and to 1,3-bis(2-chloroethyl)-1-Nitrosourea

โœ Scribed by Twentyman, P R; Bleehen, N M


Book ID
109833222
Publisher
Nature Publishing Group
Year
1973
Tongue
English
Weight
893 KB
Volume
28
Category
Article
ISSN
0007-0920

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Pretreatment of 9L cells with either a-difluoromethylornithine (DFMO), which depletes intracellular levels of polyamines, or 6-thioguanine (6TG). which substitutes for guanine in DNA, potentiates the cytotoxic effects of 1,3-bis (2-chloroethy1)-I -nitrosourea (BCNU). We examined the effects of these