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The selectivity of DG-5128 as an α2-adrenoceptor antagonist

✍ Scribed by Kyozo Yamanaka; Shigeru Kigoshi; Ikunobu Muramatsu

Book ID
115878281
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
268 KB
Volume
106
Category
Article
ISSN
0014-2999

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A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective alpha 2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analo