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The Selective Reaction of Primary Amines with Carbonyl Imidazole Containing Compounds: Selective Amide and Carbamate Synthesis

โœ Scribed by Rannard, Steve P.; Davis, Nicola J.


Book ID
111871272
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
111 KB
Volume
2
Category
Article
ISSN
1523-7060

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โœ Wei Wang; John S. McMurray ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 192 KB

A new method for the synthesis of primary amides was developed in which carboxylic acids were treated with ammonium chloride in the presence of peptide synthesis coupling agents and base at room temperature. These mild conditions allow the conversion of carboxyl groups to primary amides on substrate