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A selective method for the preparation of primary amides: Synthesis of Fmoc-l-4-carboxamidophenylalanine and other compounds

✍ Scribed by Wei Wang; John S. McMurray

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
192 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new method for the synthesis of primary amides was developed in which carboxylic acids were treated with ammonium chloride in the presence of peptide synthesis coupling agents and base at room temperature. These mild conditions allow the conversion of carboxyl groups to primary amides on substrates possessing sensitive functional groups such as esters and the base-labile Fmoc protecting group.

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A simple method for the preparation and
A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles
✍ Benjamin E Blass; Anil Srivastava; Keith R Coburn; Amy L Faulkner; William L Sei πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 155 KB

A simple procedure for the synthesis and further functionalization of 4,5-diaminopyrazoles using mild conditions is reported herein. The desired products were obtained in good yield, and the structures have been confirmed by X-ray crystallography.