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The selective isolation of temperature-sensitive mutants of Rous sarcoma virus

โœ Scribed by John A. Wyke

Book ID
119008672
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
349 KB
Volume
52
Category
Article
ISSN
0042-6822

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Temperature-sensitive dna polymerase from rous sarcoma virus mutants
โœ David Baltimore; Inder M. Verma; Stanley Drost; William S. Mason ๐Ÿ“‚ Article ๐Ÿ“… 1974 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 251 KB

T h e DNA polymerase ("reverse transcriptase") has been isolated from virions of two temperature-sensitive Rous sarcoma virus mutants (ts335 a n d ts337). These mutants are defective a t a n early stage of both growth a n d transformation. The purified polymerase is three-fold more rapidly inactivat