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DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile

✍ Scribed by Verma, Inder M.; Mason, William S.; Drost, Stanley D.; Baltimore, David

Book ID
109692625
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
520 KB
Volume
251
Category
Article
ISSN
0028-0836

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Temperature-sensitive dna polymerase fro
Temperature-sensitive dna polymerase from rous sarcoma virus mutants
✍ David Baltimore; Inder M. Verma; Stanley Drost; William S. Mason πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 251 KB

T h e DNA polymerase ("reverse transcriptase") has been isolated from virions of two temperature-sensitive Rous sarcoma virus mutants (ts335 a n d ts337). These mutants are defective a t a n early stage of both growth a n d transformation. The purified polymerase is three-fold more rapidly inactivat