The Selective Estrogen Receptor Modulator, Raloxifene: Reproductive Assessments in Adult Male Rats
โ Scribed by Judith A Hoyt; Lawrence F Fisher; D.Kim Swisher; Richard A Byrd; Paul C Francis
- Book ID
- 114274180
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 205 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0890-6238
No coin nor oath required. For personal study only.
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## Abstract **BACKGROUND:** Lasofoxifene is a nonsteroidal selective estrogen receptor modulator (SERM) with greater than 100โfold selectivity against all other steroid receptors and is a potentially superior treatment for postmenopausal osteoporosis. The purpose of this study was to evaluate the e
Raloxifene i s a selective estrogen receptor modulator known to have antiestrogenic effects o n uterine tissue. In this study, the effects of raloxifene on uterine explant growth were evaluated in rats. Rats were ovariectomized, implanted with an estradiol pellet, and an endometriosis-like state was