𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of the selective estrogen receptor modulator raloxifene on explanted uterine growth in rats

✍ Scribed by D. Kim Swisher; Robert M. Tague; David E. Seyler

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
282 KB
Volume
36
Category
Article
ISSN
0272-4391

No coin nor oath required. For personal study only.

✦ Synopsis

Raloxifene i s a selective estrogen receptor modulator known to have antiestrogenic effects o n uterine tissue. In this study, the effects of raloxifene on uterine explant growth were evaluated in rats. Rats were ovariectomized, implanted with an estradiol pellet, and an endometriosis-like state was artificially created by suturing uterine explants near mesenteric blood vessels.

Approximately 21 days after explant surgery, rats with confirmed uterine explant growth were given raloxifene orally at doses of 0 or 10 mgikgiday for 7 or 14 days. After 7 days of raloxifene treatment, explant weight and volume were significantly decreased. Fourteen days of raloxifene treatment, also caused a decrease in explant weight and volume, though not statistically significant. In addition, raloxifene treatment caused weight of the remaining uterine horn to decrease. Histological examination of the explants confirmed the presence of endometrial tissue similar to that seen in the uterus. In this study, raloxifene suppressed explanted uterine growth in a rat model designed to mimic human endometriosis. o 1995 WiIey-Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Trace LC/MS/MS quantitation of 17Ξ²-estra
Trace LC/MS/MS quantitation of 17Ξ²-estradiol as a biomarker for selective estrogen receptor modulator activity in the rat brain
✍ Chris Petucci; Tom Lloyd; Heather A. Harris; Xiaochun Zhang; Vargheese M. Chenna πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 142 KB

## Abstract A sensitive LC/MS/MS method has been developed by derivatization of 17β‐estradiol (E2) with dansyl chloride to quantitate 17β‐E2 in female rat serum. The use of E2‐d~5~ minimized interferences from endogenous 17β‐E2 in order to achieve a limit of quantitation (LOQ) of 2.5 pg/ml using 15

Endocrine mechanisms for the formation o
Endocrine mechanisms for the formation of sex-related differences in hepatic estrogen receptor content and their significance for the realization of an estrogen effect on angiotensinogen blood level in rats
✍ Lidia L. Ignatenko; Guranda D. Mataradze; Victor B. Rozen πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 710 KB

Sexual differentiation affects various aspects of mammalian liver function. It represents a result of the direct and indirect programming (irreversible) and regulating (reversible) effects of androgens and estrogens and the regulatory actions of other hormonal factors (1-3). The problem of sexual d

Beneficial effect of pharmacological mod
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: Comparison with uremic encephalopathy
✍ Petra Steindl; Andreas PΓΌspΓΆk; Wilfred Druml; Peter Ferenci πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 605 KB

Hepatic encephalopathy is ameliorated by drugs acting on the central GABA,-benzodiazepine receptor complex. To investigate whether these effects are specific for hepatic encephalopathy or just reflect a nonspecific aroa~al reaction, various benzodiazepine antagonists like flumazenil or with inverse