Endocrine mechanisms for the formation of sex-related differences in hepatic estrogen receptor content and their significance for the realization of an estrogen effect on angiotensinogen blood level in rats
✍ Scribed by Lidia L. Ignatenko; Guranda D. Mataradze; Victor B. Rozen
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 710 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Sexual differentiation affects various aspects of mammalian liver function. It represents a result of the direct and indirect programming (irreversible) and regulating (reversible) effects of androgens and estrogens and the regulatory actions of other hormonal factors (1-3).
The problem of sexual differences in the hepatic estrogen receptors (ERs) content in rats remains unclear. Its solution may be of great significance for understanding some peculiarities of metabolic processes in the male and female liver if one takes into account all the data about the direct effects of estrogens in liver cells. Moreover, it is vital for revealing the pathogenesis of many widespread sex-related diseases associated with some disturbances in liver functions (e.g., atherosclerosis, hypertension, cholesterol gallstones). Contradictions in data concerning the sexual differentiation of hepatic ER level (4-6) probably account for the par-