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The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys

✍ Scribed by R. Jeroen Vermeulen; Benjamin Drukarch; M.C. Rob Sahadat; Cornelis Goosen; Erik Ch. Wolters; Johannes C. Stoof

Book ID
115888910
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
442 KB
Volume
235
Category
Article
ISSN
0014-2999

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The dopamine D1 agonist SKF 81297 and th
The dopamine D1 agonist SKF 81297 and the dopamine D2 agonist LY 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys
✍ R. J. Vermeulen; Dr. B. Drukarch; M. C. R. Sahadat; C. Goosen; E. C. Wolters; J. πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 902 KB

## Abstract At present, the pharmacotherapy of Parkinson's disease (PD) consists mainly of L‐dihydroxyphenylalanine (L‐DOPA) and/or dopamine D~2~ receptor agonist. However, in general the clinical efficacy of D~2~ agonists is less than that of L‐DOPA. Therefore, attention is being focussed on the r