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Selective Full Dopamine D1-Like (SKF-82958) and D2-Like (N-0923) Agonist Combination in the MPTP Monkey Model of Hemiparkinsonism

✍ Scribed by Edward F Domino


Book ID
117502419
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
205 KB
Volume
43
Category
Article
ISSN
0361-9230

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## Abstract Certain aminotetralins are known to be potent dopamine D~2~ receptor agonists. N‐0923, [‐]2‐(N‐propyl‐N‐2‐thienylethylamino)‐5‐hydroxytetralin HCl, recognizes the high and low affinity states of the D~2~ receptor in membranes from bovine caudate with a K~low~ of 79 nM. The selectivity r