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The secretory function of adipocytes in the physiology of white adipose tissue

✍ Scribed by Ping Wang; Edwin Mariman; Johan Renes; Jaap Keijer

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 172 KB
Volume: 216
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21386

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✦ Synopsis

Abstract

White adipose tissue, previously regarded as a passive lipid storage site, is now viewed as a dynamic tissue. It has the capacity to actively communicate by sending and receiving different types of signals. An overview of these signals, the external modulators that affect adipose tissue and the secreted signaling molecules, the adipokines, is presented. The secretory function is highlighted in relation to energy metabolism, inflammation and the extracellular matrix and placed in the context of adipose tissue biology. We observe that the endocrine function of adipocytes receives much attention, while its paracrine and autocrine functions are underestimated. Also, we provide examples that species specificity should not be neglected. We conclude that adipose tissue primarily is an energy storage organ, well supported by its secretory function. J. Cell. Physiol. 216: 3–13, 2008. © 2008 Wiley‐Liss, Inc.

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