✦ LIBER ✦

The steroid hormone receptors in tumors of adipose tissue

✍ Scribed by P. K. Chaudhuri; M. J. Walker; C. W. Beattie; T. K. Das Gupta

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 273 KB
Volume: 28
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930280203

No coin nor oath required. For personal study only.

✦ Synopsis

The clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tumors of adipose tissue origin. All specimens were assayed for the steroid hormone receptors by charcoal dextran technique and analyzed by the method of Scatchard. The results show a high incidence of cytosolic estrogen and glucocorticoid receptors in tumors of adipose tissue origin except in lipoma and well differentiated liposarcoma. The binding parameter of these receptors suggests that the receptors may be responsive to physiologic steroid hormonal milieu.

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