✦ LIBER ✦

The scope of receptor editing and its association with autoimmunity

✍ Scribed by Laurent K Verkoczy; Annica S Mårtensson; David Nemazee

Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 146 KB
Volume: 16
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2004.09.017

No coin nor oath required. For personal study only.

✦ Synopsis

Random assembly of antibody variable (V), diversity (D) and joining (J) gene segments creates a vast repertoire of antigen receptors, including autoreactive ones. Three ways that are known to reduce autoreactivity in the B-cell compartment include clonal deletion, functional inactivation and receptor editing, a mechanism involving a change in antigen receptor specificity through continued V(D)J recombination. New data suggest that editing can efficiently eliminate autoreactivity, yet, in an autoimmune context, secondary antibody gene rearrangements might also contribute to autoimmunity.

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