✦ LIBER ✦
A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases
✍ Scribed by Marcos Timón; Antonio Arnaiz-Villena; Paloma Pérez-Aciego; Pablo Morales; Djamal Benmamar; José R. Regueiro
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 236 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
A diallelic restriction fragment length polymorphism of the CD3-epsilon (e) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-e chain cDNA probe. This combination shows two alleles of 9.1 kb and 8.4 kb with a frequency of 0.66 and 0.34, respectively, in the Spanish population. None of these alleles is associated with susceptibility to juvenile rheumatoid arthritis (JRA) or insulin-dependent diabetes mellitus (IDDM).