The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement
β Scribed by Clayton C. Caswell; Runlin Han; Kelley M. Hovis; Pawel Ciborowski; Douglas R. Keene; Richard T. Marconi; Slawomir Lukomski
- Book ID
- 110834760
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 385 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0950-382X
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Complement regulatory proteins present on the surface of various mammalian cells play an important role in controlling homologous lysis, by interacting with C3 (and usually C4). These proteins have a similar structural motif ("short consensus repeat") (Reid, K.B.