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The SCF ubiquitin ligase: insights into a molecular machine

โœ Scribed by Cardozo, Timothy; Pagano, Michele


Book ID
109958215
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
382 KB
Volume
5
Category
Article
ISSN
1471-0072

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The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i