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The roles of the eukaryotic DNA polymerases in DNA repair synthesis

✍ Scribed by Martin E Budd; Judith L Campbell


Book ID
117614532
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
99 KB
Volume
384
Category
Article
ISSN
0921-8777

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## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint