The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients
โ Scribed by Maureen A. Su; Matthew Stenerson; Weihong Liu; Amy Putnam; Felix Conte; Jeffrey A. Bluestone; Mark S. Anderson
- Book ID
- 113540731
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 473 KB
- Volume
- 131
- Category
- Article
- ISSN
- 1090-2341
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The gene WAS, contained in this interval, was excluded as a candidate for IPEX (refs. 1,2). The scurfy syndrome in mice 3 shares phenotypic features with IPEX and maps to a region of conserved synteny on the mouse X chromosome. Human and mouse FOXP3 were recently identified by positional cloning and
Cytogenetic analyses have previously shown that the region Xq11.2-q21 is retained in all structurally abnormal X chromosomes. From these observations the conclusion has been drawn that this "critical region" on the proximal long arm of the X chromosome contains the locus controlling X-inactivation.