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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

โœ Scribed by Ochs, Hans D.; Bennett, Craig L.; Christie, Jacinda; Ramsdell, Fred; Brunkow, Mary E.; Ferguson, Polly J.; Whitesell, Luke; Kelly, Thaddeus E.; Saulsbury, Frank T.; Chance, Phillip F.

Book ID
109829791
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
44 KB
Volume
27
Category
Article
ISSN
1061-4036

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The immune dysregulation, polyendocrinop
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
โœ Ochs, Hans D.; Bennett, Craig L.; Christie, Jacinda; Ramsdell, Fred; Brunkow, Ma ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 44 KB

The gene WAS, contained in this interval, was excluded as a candidate for IPEX (refs. 1,2). The scurfy syndrome in mice 3 shares phenotypic features with IPEX and maps to a region of conserved synteny on the mouse X chromosome. Human and mouse FOXP3 were recently identified by positional cloning and