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The Role of Vitamin A Status in the Conversion of All-Trans Retinoyl β-Glucuronide to Retinoic Acid in Male Sprague-Dawley Rats

✍ Scribed by Arun B Barua; Pamela K Duitsman; James A Olson


Book ID
108474067
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
321 KB
Volume
9
Category
Article
ISSN
0955-2863

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All-trans-retinoyl-beta-D-glucuronide (all-trans-RAG) is a water-soluble derivative of all-trans-retinoic acid (all-trans-RA) and has been characterized as an endogenous metabolite of vitamin A in rat bile and kidney. All-trans-RAG was previously demonstrated to be a major metabolite after applicati

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All-trans-retinoyl-b-D-glucuronide (RAG) is an endogenous active metabolite of all-trans-retinoic acid (ATRA). In the present study, the pharmacokinetics of RAG was examined after the administration of a single intravenous does (5, 10, or 15 mmol/kg) and of multiple daily intravenous doses (5 mmol/k