All-trans-retinoyl-beta-D-glucuronide (all-trans-RAG) is a water-soluble derivative of all-trans-retinoic acid (all-trans-RA) and has been characterized as an endogenous metabolite of vitamin A in rat bile and kidney. All-trans-RAG was previously demonstrated to be a major metabolite after applicati
✦ LIBER ✦
All-trans-retinoic acid and all-trans-retinoyl-β-d-glucuronide alter the development of axolotl embryos (Ambystoma mexicanum) in vitro
✍ Scribed by Renate Krätke; Ralph Rühl; Frank Kirschbaum; Heinz Nau
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 566 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-5761
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BACKGROUND: Retinoic acid (RA) is a vitamin A derivative that participates in patterning and regulation of inner ear development. Either excess RA or RA deficiency during a critical stage of inner ear development can produce teratogenic effects. Previous studies have shown that in utero exposure of