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The role of VEGF and thrombospondins in skin angiogenesis

✍ Scribed by Detmar, Michael


Book ID
119560800
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
95 KB
Volume
24
Category
Article
ISSN
0923-1811

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Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumo