The role of urokinase type plasminogen activator (u-PA) and u-PA receptor (u-PAR) in the invasion of human hepatocellular carcinoma cell lines
โ Scribed by Toshiya Kamiyama; Yoshie Une; Junichi Uchino
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 560 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1341-9625
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In LLC-PK, porcine epithelial cells, the urokinase-type plasminogen activator (u-PA) mRNA and protein can be induced either by stimulation of the protein kinase C (PKC) pathway using a tumor promoter (PMA) or by stimulation of the protein kinase A (PKA) pathway with calcitonin SCT). By PKC, to LLC-P
The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immunoยฏ