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The Role of Transforming Growth Factor-β1, Vascular Endothelial Growth Factor, ALK1, and Endoglin in the Pathogenesis of Osler‘s Disease

✍ Scribed by Haneen Sadick; Frank Riedel; Ramin Naim; Ulrich R. Goessler; Karl Hoermann


Book ID
116810859
Publisher
SAGE Publications
Year
2005
Tongue
English
Weight
56 KB
Volume
133
Category
Article
ISSN
0194-5998

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## Abstract Transforming growth factor‐β (TGF‐β) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK‐1 are components of the TGF‐β receptor complex, predominantly expressed i