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The role of torsinA in dystonia

✍ Scribed by A. Granata; T. T. Warner

Book ID: 111066380
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 117 KB
Volume: 17
Category: Article
ISSN: 1351-5101
DOI: 10.1111/j.1468-1331.2010.03057.x

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## Abstract A three‐nucleotide (GAG) deletion in the __TOR1A__ gene is the most common cause of inherited dystonia, DYT1. Because the mutant protein, TorsinA (TA), is thought to act in a dominant manner to cause disease, inhibiting expression from the mutant gene represents a potentially powerful t