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Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

✍ Scribed by Cao, S.; Hewett, J. W.; Yokoi, F.; Lu, J.; Buckley, A. C.; Burdette, A. J.; Chen, P.; Nery, F. C.; Li, Y.; Breakefield, X. O.; Caldwell, G. A.; Caldwell, K. A.

Book ID
124094008
Publisher
The Company of Biologists
Year
2010
Tongue
English
Weight
759 KB
Volume
3
Category
Article
ISSN
1754-8403

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Cultured mammalian cells, particularly Chinese hamster ovary (CHO) cells, are widely exploited as hosts for the production of recombinant proteins, but often yields are limiting. Such limitations may be due in part to the misfolding and subsequent degradation of the heterologous proteins. Consequent