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The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis

✍ Scribed by Winckers, Kristien; ten Cate, Hugo; Hackeng, Tilman M.

Book ID
120407594
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
1005 KB
Volume
27
Category
Article
ISSN
0268-960X

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Tissue factor (TF) initiates the extrinsic pathway of blood coagulation by acting as a cofactor for Factor VII. Inhibition of the Factor VIIa-TF complex is mediated by the tissue factor pathway inhibitor (TFPI), which is a serine protease inhibitor with three Kunitz-type domains. The localization of