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The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases

✍ Scribed by Norbert Thuerauf; Martin Friedrich Fromm


Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
94 KB
Volume
256
Category
Article
ISSN
1433-8491

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For years, P-glycoprotein (P-gp) has been purported to be a membrane transporter capable of selectively transporting many (but not all) lipophilic anticancer drugs with diverse chemical structures. Because the alleged functions of P-gp provide a straightforward, near-perfect explanation for the mole