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The role of the tissue adhesive fibrin seal (FS) in esophageal anastomoses

✍ Scribed by G. K. Thorson; R. Perez-Brett; D. B. Lillie; J. L. Ambrus; C. Karakousis; H. Takita; P. D. Williams; M. M. Reddington; H. Cohen

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 192 KB
Volume: 24
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930240317

No coin nor oath required. For personal study only.

✦ Synopsis

Following surgical removal of esophageal tumors, leakage and mediastinitis is a frequent and often fatal complication. A new method has been developed to seal suture lines in the esophagus with preparations containing fibrinogen, cold insoluble globulin, factor XIII, antiplasmin, platelet growth factor, thrombin, and calcium chloride. In experimental animals operated on by standard methods, esophageal leakage developed in 50% of the animals and death in 40%. By contrast, in treated animals, esophageal leak and death developed in only 20%. More adhesions were found in treated animals than in control animals.

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