The Role of the Tec Kinase Bruton's Tyrosine Kinase (Btk) in Leukocyte Recruitment
β Scribed by Block, Helena; Zarbock, Alexander
- Book ID
- 111898592
- Publisher
- Informa plc
- Year
- 2012
- Tongue
- English
- Weight
- 424 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0883-0185
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π SIMILAR VOLUMES
## X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton agammaglobulinemia tyrosine kinase (BTK). A database (BTKbase ) of BTK mutations lists 544 mutation entries from 471 unrelated families showing 341 unique molecular events. In addition to
## Abstract Cytoplasmic proteinβtyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans. The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cau