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The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair

โœ Scribed by Patrick S. Lin; Lisa A. McPherson; Aubrey Y. Chen; Julien Sage; James M. Ford


Book ID
113568082
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
675 KB
Volume
8
Category
Article
ISSN
1568-7864

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โœ Don X. Nguyen; Dennis J. McCance ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 111 KB

## Abstract The retinoblastoma protein (pRb105) is a true tumor suppressor as deregulation of the Rb pathway by either mutation of pRb105 itself or other proteins in the pathway, such as p16INK4a, occur in most cancers. This prototypical family member, along with the related p107 and p130, are invo