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The role of the proteasome in the generation of MHC class I ligands and immune responses

✍ Scribed by E. J. A. M. Sijts; P.-M. Kloetzel

Publisher: Springer
Year: 2011
Tongue: English
Weight: 243 KB
Volume: 68
Category: Article
ISSN: 1420-682X
DOI: 10.1007/s00018-011-0657-y

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## Abstract Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for the presentation of CD8^+^ T cells. Three IFN‐γ‐inducible catalytic proteasome (immuno)subunits as well as the IFN‐γ‐inducible proteasome activator PA28 d