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The role of the proteasome activator PA28 in MHC class I antigen processing

✍ Scribed by Alice Sijts; Yuancheng Sun; Katarina Janek; Sylvie Kral; Annettte Paschen; Dirk Schadendorf; Peter-M Kloetzel

Book ID
117325490
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
69 KB
Volume
39
Category
Article
ISSN
0161-5890

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## Abstract Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for the presentation of CD8^+^ T cells. Three IFN‐γ‐inducible catalytic proteasome (immuno)subunits as well as the IFN‐γ‐inducible proteasome activator PA28 d