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The components of the proteasome system and their role in MHC class I antigen processing

✍ Scribed by E. Krüger; U. Kuckelkorn; A. Sijts; P.-M. Kloetzel

Publisher: Springer Berlin Heidelberg
Year: 2003
Tongue: German
Weight: 323 KB
Volume: 148
Category: Article
ISSN: 0080-2042
DOI: 10.1007/s10254-003-0010-4

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## Abstract Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for the presentation of CD8^+^ T cells. Three IFN‐γ‐inducible catalytic proteasome (immuno)subunits as well as the IFN‐γ‐inducible proteasome activator PA28 d