✦ LIBER ✦

The role of the organ microenvironment in the biology and therapy of cancer metastasis

✍ Scribed by Isaiah J. Fidler; Sun-Jin Kim; Robert R. Langley

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 102 KB
Volume: 101
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.21148

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

By the time of diagnosis, primary neoplasms are biologically heterogeneous and contain subpopulations of cells with different metastatic potentials. The pathogenesis of a metastasis consists of many sequential steps that must be completed to produce clinically relevant lesions. During any of these steps, tumor cells interact with host factors in the microenvironment that the tumor cells can usurp. Treatment of metastasis can be directed against tumor cells and/or microenvironmental factors that support tumor growth, such as tumor‐associated blood vessels. J. Cell. Biochem. 101: 927–936, 2007. © 2006 Wiley‐Liss, Inc.

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