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The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

✍ Scribed by Matkovic, K; Brugnoli, F; Bertagnolo, V; Banfic, H; Visnjic, D


Book ID
110056723
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
601 KB
Volume
20
Category
Article
ISSN
0887-6924

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev