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Effect of all trans retinoic acid on lysosomal α-d-mannosidase activity in Hl-60 cell: correlation with Hl-60 cells differentiation

✍ Scribed by Leda Racanicchi; Pia Montanucci; Giuseppe P. P. Basta; Alessandra Pensato; Valentina Conti; Riccardo Calafiore


Publisher
Springer
Year
2007
Tongue
English
Weight
243 KB
Volume
308
Category
Article
ISSN
0300-8177

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev