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Effects of all-trans retinoic acid on hTERT gene expression and telomerase activity of HL-60 cells

✍ Scribed by He Dongmei; Zhang Yuan


Publisher
Springer
Year
2003
Tongue
English
Weight
364 KB
Volume
2
Category
Article
ISSN
1610-1979

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev