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The role of the LD50 determination in drug safety evaluation

โœ Scribed by LeBeau, Joseph E.

Book ID
122074111
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
296 KB
Volume
3
Category
Article
ISSN
0273-2300

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The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation wit