✦ LIBER ✦

Evaluation of drug formulations using LD50 testing in mice

✍ Scribed by P. R. Sheth; N. H. Shah; W. Pool

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 427 KB
Volume: 66
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600661117

No coin nor oath required. For personal study only.

✦ Synopsis

The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation with hydrophilic agents. Differences in toxicities were demonstrated from formulations compared to pure drugs by the LD50 method. This study shows that the LD50 is a practical, rapid method of achieving comparative evaluations of drug formulations.

📜 SIMILAR VOLUMES

Nonvariance of LD50 values of drugs in g

Nonvariance of LD50 values of drugs in gravid and nongravid mice

✍ James A. Russell; Michael P. Mahalik; Joseph M. McDevitt; Ronald F. Gautieri 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 220 KB 👁 1 views

Effects of depot drug formulations in pr

Effects of depot drug formulations in procedures used to evaluate antipsychotic activity in rodents

✍ Sarah Lister; Stephen M. Sorensen; Janice M. Hitchcock; Joseph G. Wettstein 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB 👁 1 views

The use of long-acting depot antipsychotics results in an increase in compliance and significantly decreases rates of relapse and rehospitalization of schizophrenic patients. However, the assessment of activity of such drugs in small animals is not as straightforward as the evaluation of acutely act

Evaluation of drug precipitation of solu

Evaluation of drug precipitation of solubility-enhancing liquid formulations using milligram quantities of a new molecular entity (NME)

✍ Wei-Guo Dai; Liang C. Dong; Xinfeng Shi; Joe Nguyen; Juli Evans; Yaodong Xu; Abl 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

Evaluation of drug-antibody conjugates i

Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice

✍ Z. A. Latif; B. B. Lozzio; C. J. Wust; S. Krauss; M. C. Aggio; C. B. Lozzio 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 710 KB

Improved pharmacokinetic and bioavailabi

Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice

✍ Sean X. Peng; Beth A. Rockafellow; Tina M. Skedzielewski; Norman D. Huebert; Wil 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 1 views

Pharmacokinetic studies in mice traditionally require one animal per time point, resulting in dosing and euthanizing a large number of animals and producing suboptimal quality of pharmacokinetic data due to inter-animal variability and dosing error. These studies are time-consuming and labor-intensi

Evaluation of drug absorption and presys

Evaluation of drug absorption and presystemic metabolism using an in situ intestinal preparation

✍ Karl A. Yorgey; J. Frederick Pritchard; Ned L. Renzi; Barry H. Dvorchik 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 389 KB 👁 2 views