The role of the Epstein-Barr virus in the oncogenesis of EBV(+) gastric carcinomas
โ Scribed by Y. Takano; Y. Kato; Makoto Saegusa; Shigeo Mori; Mami Shiota; Mitsunobu Masuda; Tetsuo Mikami; Isao Okayasu
- Book ID
- 106118772
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 171 KB
- Volume
- 434
- Category
- Article
- ISSN
- 1432-2307
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## Abstract Twentyโone cases of gastric carcinoma were tested for the presence of EpsteinโBarr virus (EBV) genome by polymerase chain reaction (PCR) analysis. EBV genome was detected in 3 (14%) of the 21 cases. In situ hybridization for EBVโencoded small RNA 1 showed that EBV genomes were present i
Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells. Recently, we found that EBERs play a key role in the maintenance of malignant phenotypes of Burkitt's lymphoma (BL) cells. They confer clonability in soft agarose, tumorigenicity in