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The role of the electrogenic sodium pump in modulation of pacemaker discharge of Aplysia neurons

✍ Scribed by James A. Willis; Gary L. Gaubatz; David O. Carpenter

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
771 KB
Volume
84
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The discharge of Aplysia pacemaker neurons varies with temperature over the range 10 to 22Β°C. Three types of frequency‐temperature plots are found, with maximal discharge at lowest, intermediate or highest temperatures. In the presence of ouabain, however, all cells show maximal discharge at the highest temperature, suggesting that the steady state activity of an electrogenic sodium pump is an important determinant of membrane excitability. The average magnitude of pump current, as indicated by the applied current necessary to restore discharge to control values after ouabain application, was about 4 namps at 20Β°C but near zero at 10Β°C. These neurons may be excellent models of mammalian thermoreceotprs.

πŸ“œ SIMILAR VOLUMES

The dependence of pacemaker discharge of
The dependence of pacemaker discharge of Aplysia neurons upon Na+ and Ca++
✍ David Carpenter; Rufus Gunn πŸ“‚ Article πŸ“… 1970 πŸ› John Wiley and Sons 🌐 English βš– 477 KB

## Abstract In total absence of Na^+^ some identified neurons of __Aplysia__, after a period of silence, resume pacemaker discharge in the normal pattern with normal action potentials, while other identified neurons remain silent. In absence of Ca^++^ all pacemaker neurons increase spontaneous disc