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The role of the CDKN2A locus in patients with multiple primary melanomas

Book ID: 116580308
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 45 KB
Volume: 52
Category: Article
ISSN: 1097-6787
DOI: 10.1016/j.jaad.2004.10.593

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CDKN2A has been found mutated in melanoma families which show linkage to chromosome 9p21. In contrast, a low mutation rate has been found in melanomas, suggesting that CDKN2A might not be the first target for mutation in the development of this type of tumour. To elucidate the role of the CDKN2A gen