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The Role of the CD40 Antigen on Malignant B Cells

โœ Scribed by Planken, E. V.; Willemze, R.; Kluin-Nelemans, J. C.


Book ID
121401554
Publisher
Informa plc
Year
1996
Tongue
English
Weight
618 KB
Volume
22
Category
Article
ISSN
1042-8194

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Stimulation of human Bcells via CD40 is known to induce their homotypic aggregation. We show here that anti-mouse CD40 monoclonal antibodies (mAb) also induce B cells to form large, spherical, extremely stable clusters. This clustering is markedly enhanced by co-stimulation with either interleukin-4